It's configured as a single RAID5 volume (4 x 3TB) using Toshiba DT01ACA300 drives (compatibility should be OK).
Recently one of the disks (disk 4) showed a red light and was reported as "missing" in the Storage Manager. Data still accessible of course, but without redundancy so needs fixing. Log showed a sequence of media errors for that disk, followed by "There is a hardware error on the slot 4 disk". (Subsequently, removing and replugging this disk showed in the log, although obviously it didn't solve the hardware error; similarly, the system reports when other disks are removed and replugged).
I bought a new Western Digital Red 3TB disk (WD30EFRX so compatibility should be fine) -- I've always had a preference for WD but the NAS originally arrived pre-populated with Toshiba disks.
Took out the defunct disk, inserted the new disk. Green light now showing on that disk, so I was expecting it to resync over a long period and then the problem was solved.

What (if anything) am I doing wrong? What else should I check? I can try the new disk in another NAS but that holds got the data-backup for the first NAS and doesn;t have any spare slots, so I'm loathe to mess around with it as a first resort.
I'll raise a support ticket with Asustor as soon as I know I'm not being a total idiot!